Project Description

The peroxisome proliferator-activated receptors (PPARs) form heterodimers with the retinoid X receptor (RXR), bind to DNA, and further regulate expression of many genes involved in energy utilization.

Reference:

1. Chandra, V. et al. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature 456, 350-356, doi:10.1038/nature07413 (2008).